Uniform Fe₃O₄/Gd₂O₃-DHCA nanocubes for dual-mode magnetic resonance imaging

• Miao Qin,
• Yueyou Peng,
• Mengjie Xu,
• Hui Yan,
• Yizhu Cheng,
• Xiumei Zhang,
• Di Huang,
• Weiyi Chen and
• Yanfeng Meng

Beilstein J. Nanotechnol. 2020, 11, 1000–1009, doi:10.3762/bjnano.11.84

• distributed Fe3O4/Gd2O3 nanocubes for T1–T2 dual-mode MRI contrast agents were successfully designed and synthesized. In order to increase hydrophilicity and biocompatibility, the nanocubes were coated with nontoxic 3,4-dihydroxyhydrocinnamic acid (DHCA). The results show that iron (Fe) and gadolinium (Gd

• MR imaging [24][25][26]. In the present study, the fabrication of novel nanocubes with uniformly distributed Fe3O4/Gd2O3 and better MRI contrast was reported. These novel nanocubes were coated with 3,4-dihydroxyhydrocinnamic acid (DHCA), which has a higher exchange efficiency and a lower toxicity in

• -dihydroxyhydrocinnamic acid (DHCA); dual-mode imaging; Fe3O4/Gd2O3-DHCA nanocubes; gadolinium oxide (Gd2O3); iron(II,III) oxide (Fe3O4); magnetic resonance imaging (MRI); Introduction Magnetic resonance imaging (MRI) is a noninvasive technique that has been broadly used in the clinical field to assist in disease

Controlling mechanical properties of bio-inspired hydrogels by modulating nano-scale, inter-polymeric junctions

• Seonki Hong,
• Hyukjin Lee and
• Haeshin Lee

Beilstein J. Nanotechnol. 2014, 5, 887–894, doi:10.3762/bjnano.5.101

• 3,4-dihydroxyhydrocinnamic acid (DHCA) and linear or 6Arm-PEG-NH2. To investigate the effect of secondary amines on the results of quinone tanning, both linear PEG derivatives, mPEG-NH-catechol and mPEG-catechol, underwent the same crosslinking reactions in phosphate buffered saline (pH 8.0 with 0.3

• (PEG-(NH2)4, Mw = 15,000 Da) and methoxy-PEG-amine (mPEG-NH2, Mw = 5,000 Da) were purchased from SunBio, Inc. (Walnut Creek, CA). Sodium periodate (NaIO4), sodium cyanoborohydride (NaBH3CN), N,N-diisopropylethylamine (DIPEA), 3,4-dihydroxyhydrocinnamic acid (DHCA) and 3,4-dihydroxybenzaldehyde (DHBA